Many eastern Indians initially welcomed the newcomers, or at least their goods, which they appreciated for their practical advantages. Items like woven cloth, metal kettles, iron axes, fishhooks, hoes, and guns were quickly integrated into Indian life. Indians also displayed a great desire for goods like colorful glass beads and copper ornaments that could be incorporated into their religious ceremonies.
As Indians became integrated into the Atlantic economy, subtle changes took place in Indian life. European metal goods changed their farming, hunting, and cooking practices. Men devoted more time to hunting beaver for fur trading. Older skills deteriorated as the use of European products expanded, and alcohol became increasingly common and disruptive. Indians learned to bargain effectively and to supply items that Europeans desired. Later observers would describe this trade as one in which Indians exchanged valuable commodities like furs and animal skins for worthless European trinkets. In fact, both Europeans and Indians gave up goods they had in abundance in exchange for items in short supply in their own society. But as the colonists achieved military superiority over the Indians, the profits of trade mostly flowed to colonial and European merchants. Growing connections with Europeans stimulated warfare among Indian tribes, and the overhunting of beaver and deer forced some groups to encroach on territory claimed by others. And newcomers from Europe brought epidemics that decimated Indian populations.

The only known contemporary portrait of a New England Indian, this 1681 painting by an unnamed artist was long thought to represent Ninigret II, a leader of the Narragansetts of Rhode Island. It has been more recently identified as David, an Indian who saved the life of John Winthrop II, a governor of colonial Connecticut. Apart from the wampum beads around his neck, everything the Indian wears is of English manufacture.